Cannabidiol (CBD) and kratom are herbal remedies that have the potential to ease substance abuse, anxiety, chronic pain, and other health conditions. However, on a molecular level, the two substances function in distinct ways and come with diverse side effects and risks.


Scientifically known as Mitragyna speciosa, kratom flourishes in Papua New Guinea, Thailand, Indonesia, and Malaysia. It is renowned for enhancing energy and managing pain and is used as an opium substitute in Southeast Asian countries.

Mytragina functions as a stimulant at low doses. However, at high doses, the substance displays opiate-like characteristics. In the past, kratom has been effective in treating ailments such as fatigue, hypertension, fever, muscle pain, and diarrhea. Today, the compound is used to treat opium withdrawal, anxiety, and chronic pain.

In addition, kratom can help increase productivity, boost energy, reduce pain, and decrease anxiety. Kratom, unlike cannabis, does not provide instant relief to the users. It takes one hour to exhibit its effects.

A study discovered that kratom can not only ease the pain but can also enhance your immune system and induce relaxation.

Kratom has been found to be efficacious in treating opioid withdrawal. The compound helps addicts wean off opioids such as fentanyl, oxycodone, and heroin.

How Does Kratom Function?

You can smoke, chew or steep kratom in your tea. Usually, it is grounded into a powder and mixed with warm water. You can also mix kratom with other foods or liquids so that you can ingest it easily.

About 25 independent alkaloids have been isolated from kratom leaves. Mitragynine (MG), kratom’s indole alkaloid, is accountable for its analgesic capability.

MG is more effective when it is taken as a whole-plant extract than when consumed as a single-molecule isolate. Whole-plant extracts comprise 7-hydroxymitragynine, a biologically active compound that interacts with the mu-opioid receptor. The structure of the compound is different from other opioids and it has an affinity for opioid receptors. The physiological properties exert themselves through neurotransmitter systems. Additionally, kratom significantly affects neurotransmitters such as GABA, serotonin, and dopamine.


CBD is a cannabinoid derived from CBD-rich marijuana strains. The compound is available in different forms such as edibles, capsules, and tinctures.

CBD has an immense potential to treat myriad psychological and physical disorders. The compound helps treat conditions such as inflammation, Crohn’s disease, stress disorders, multiple sclerosis, anxiety, and epilepsy.

CBD exerts several effects through diverse pathways. The compound does not bind to the cannabinoid receptors CB1 and CB2. Instead, it acts upon them indirectly.

CBD induces its effects by stimulating the receptors and using them to influence bodily functions such as temperature, inflammation, and pain perception.

Risks and Side Effects of CBD

Cannabidiol is a non-psychoactive and non-addictive drug. As a matter of fact, research shows that the herb helps treat substance withdrawal by inhibiting the release of the pleasure hormone dopamine. Individuals who take CBD need not worry about mind-altering and addictive effects.

Side effects of CBD include changes in appetite, dizziness, diarrhea, dry mouth, vomiting, nausea, and drowsiness. However, the occurrence of these side effects is rare and if you stop using the drug, these side effects will not continue.

Cannabidiol may interact with other medications such as epileptic medications. Therefore, if you are thinking of using prescription medication and CBD concomitantly, speak to your doctor first.


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